A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy

Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physiological mediators that activate programmed cell death (apoptosis) are Fas and Fas Ligand (FasL). Materials and Methods: In a thesis study conducted by our authors in 2004, we investigated the relationship of Fas-Fas ligand-mediated apoptosis with survival in laryngeal cancer, prognostic factors (age, localization, histological grade, tumor size, lymph, blood vessel invasion), stage, and inflammatory response of the tumor. In this study, we investigated the relationship between survival and death rates after 20 years and Fas-FasL. Results: When FAS was evaluated 20 years later, a statistically significant difference was found between mortality rates depending on stage (p=0.023; p0.05). Conclusion: In conclusion, we found that the Fas/Fas-L system was not associated with clinical parameters in laryngeal cancers in our short-term follow-up. However, when we repeated our follow-up 20 years later, we found that Fas system deficiency, although not in FAS Ligand, adversely affected survival in the long term in laryngeal cancer patients

Bir orta öğretim formatı olarak sosyal lise

Bu çalışmanın amacı; Türkiye’de Milli Eğitim Bakanlığı tarafından uygulanan lise formatlarına ek olarak yeni bir öneri getirmektir. Bu öneri; yeteneğin doğru ve zamanında tespit ve yönlendirilmesini esas alan bir çerçevede yapılmaktadır. Hareket noktası; orta öğretim kurumlarında üniversitelerdeki sosyal bilimler eğitimine alt yapı teşkil eden bir lise formatının bulunmamasıdır. Bu doğrultuda bu tür bir lise formatının gerekçeleri ve ana çerçevesi çizilmektedir. Bununla birlikte, sosyal bilimler eğitiminin günümüzde kazandığı stratejik öneme vurgu yapılmaktadır

From Big Data to Big Displays: High-Performance Visualization at Blue Brain

Blue Brain has pushed high-performance visualization (HPV) to complement its HPC strategy since its inception in 2007. In 2011, this strategy has been accelerated to develop innovative visualization solutions through increased funding and strategic partnerships with other research institutions. We present the key elements of this HPV ecosystem, which integrates C++ visualization applications with novel collaborative display systems. We motivate how our strategy of transforming visualization engines into services enables a variety of use cases, not only for the integration with high-fidelity displays, but also to build service oriented architectures, to link into web applications and to provide remote services to Python applications.Comment: ISC 2017 Visualization at Scale worksho

Retrospectively Analysis of Clinical/Pathological and Prognostic Features of Subtypes of Breast Cancer

DergiPark: 379007tmsjAims: Breast cancer is the most common type of cancer among all women across the world, with an incidence of 25.2%. Of all the cancer cases, breast cancer comes second in line after lung cancer. By 6.4% it marks fifth place as the reason for cancer-related-deaths. Therefore new studies on breast cancer are required. We aimed to retrospectively analyze clinical, pathological and prognostic features of cases that were divided into four subgroups based on their hormone receptor and HER-2 conditions. Method: Records of GATA-Oncology Clinic patients who have been diagnosed with breast cancer within years of 2008-2014, were inspected retrospectively. Cases were divided into four subgroups based on their hormone receptor and HER-2 conditions. Missing records were primarily gathered by electronic recording system, also still-missing-information about the patients were provided via phone calls. Collected data has been evaluated with SPSS 15,0. Results: While demographics such as family history and menopausal state were not different among 4 subgroups, triple negative patients tended to have a lower body-mass index and mean age (p=009, p=0.041, respectively). Only 12 patients had advanced disease at diagnosis. A total of 168 patients received chemotherapy. Progression occurred in 41 patients (21.9%) from early phase breast cancer cases that were taken to adjuvant chemotherapy program. Family history had a significant association with recurrence in breast cancer patients (p=0.026). Menopausal state, lymphovascular invasion, lymph node state and stage were not associated with progression. Independent prognostic factors were not obtained with multivariate analysis for disease-free survival. Advanced stage breast cancer patients had a higher tendency to metastasis. Triple negative patients had more drug resistance towards systemic treatment than other subgroups (p lt;0.001). It has been found that full response to anthracycline + taxane regime was less in triple negative patients. Conclusion: In conclusion, there were some differences within our subgroups. Patients of these subgroups should be followed up and treated with different strategies. All subgroups, especially triple negative group, were in need of new effective therapy strategies

Physically-based in silico light sheet microscopy for visualizing fluorescent brain models

We present a physically-based computational model of the light sheet fluorescence microscope (LSFM). Based on Monte Carlo ray tracing and geometric optics, our method simulates the operational aspects and image formation process of the LSFM. This simulated, in silico LSFM creates synthetic images of digital fluorescent specimens that can resemble those generated by a real LSFM, as opposed to established visualization methods producing visually-plausible images. We also propose an accurate fluorescence rendering model which takes into account the intrinsic characteristics of fluorescent dyes to simulate the light interaction with fluorescent biological specimen

Oncological outcomes of visibly complete transurethral resection prior to neoadjuvant chemotherapy for bladder cancer

ABSTRACT Purpose: To evaluate the potential oncologic benefit of a visibly complete transurethral resection of a bladder tumor (TURBT) prior to neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Materials and Methods: We identified patients who received NAC and RC between 2011-2021. Records were reviewed to assess TURBT completeness. The primary outcome was pathologic downstaging (<ypT2N0), with complete pathologic response (ypT0N0) and survival as secondary endpoints. Logistic regression and Cox proportional hazards models were utilized. Results: We identified 153 patients, including 116 (76%) with a complete TURBT. Sixty-four (42%) achieved <ypT2N0 and 43 (28%) achieved ypT0N0. When comparing those with and without a complete TURBT, there was no significant difference in the proportion with <ypT2N0 (43% vs 38%, P=0.57) or ypT0N0 (28% vs 27%, P=0.87). After median follow-up of 3.6 years (IQR 1.5-5.1), 86 patients died, 37 died from bladder cancer, and 61 had recurrence. We did not observe a statistically significant association of complete TURBT with cancer-specific or recurrence-free survival (p≥0.20), although the hazard of death from any cause was significantly higher among those with incomplete TURBT even after adjusting for ECOG and pathologic T stage, HR 1.77 (95% CI 1.04-3.00, P=.034). Conclusions: A visibly complete TURBT was not associated with pathologic downstaging, cancer-specific or recurrence-free survival following NAC and RC. These data do not support the need for repeat TURBT to achieve a visibly complete resection if NAC and RC are planned

Reconstruction and simulation of neocortical microcircuitry

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies